Principal Scientist I, Analytics & Separation Specialist, Oligonucleotide Research

Company: F. Hoffmann-La Roche Gruppe
Location: Pleasanton
Posted on: November 9, 2024

Job Description:

Roche fosters diversity, equity and inclusion, representing the communities we serve. When dealing with healthcare on a global scale, diversity is an essential ingredient to success. We believe that inclusion is key to understanding people's varied healthcare needs. Together, we embrace individuality and share a passion for exceptional care. Join Roche, where every voice matters.The PositionWe advance science so that we all have more time with the people we love.Roche Diagnostics is looking for a highly motivated and skilled Principal Scientist, Analytics & Separation Specialist in Oligonucleotide Research (Scientist) to support the development of advanced molecular diagnostics technologies. This role involves hands-on expertise in preparative chromatography and analytical techniques throughout the product development lifecycle, from early research to on-market support. As part of the Chemistry Team, you will have access to cutting-edge technologies and state-of-the-art instrumentation, enabling you to contribute meaningfully to advancements in molecular diagnostics. Your work will directly impact global health, pushing the boundaries of what's possible in the field of diagnostics.Key Responsibilities:

• You have demonstrated experience purifying, analyzing, and characterizing complex oligonucleotides and related analogs.
• You have the ability to develop innovative analytical methods for reagents and assay performance, applicable in R&D and Operations; supporting scale-up and launch efforts.
• You have the ability to design and execute advanced troubleshooting experiments in coordination with collaborators; demonstrated experience developing creative assays to understand and detect system defects.
• You have the ability to support documentation transfer, specifically of prototype methods and documentation from research to development and manufacturing.
• You will serve as a subject matter expert and provide expertise across R&D departments (oligo synthesis & purification, assay development) and operations.This position is based on-site in Pleasanton, CA.Relocation benefits are not offered for this role.Who You Are:(Requirements)
  • You have a Bachelor's or Master's Degree (preferred) in Chemistry, Biochemistry, Chemical Biology, Medical Chemistry (or related field) with 7+ years of industry experience; or a Ph.D. with 3+ years of relevant industry experience in Chemistry, Biochemistry, Chemical Biology, Medical Chemistry (or related field).
  • You have comprehensive experience and problem-solving skills in UPLC/HPLC, ion pair chromatography, ion exchange, mass spectrometry, absorption, and fluorescence spectroscopy.
  • You are proficient in oligonucleotide purification and characterization.
  • You have demonstrated experience in DNA, RNA, non-natural modifications, and dye-modifications; you demonstrated experience in designing and optimizing analytical assays.
  • You have demonstrated communication and organizational skills, including technical writing skills for detailed documentation/report preparation; excellent verbal and written communication skills for effective team collaboration.Preferred:
    • You have proficiency organizing and maintaining a research laboratory.
    • You have experience with automated DNA synthesis, phosphoramidite chemistry, and click-chemistry.
    • You have working knowledge of PCR and/or other amplification technologies.This position is based on-site in Pleasanton, CA.Relocation benefits are not offered for this role.The expected salary range for this position based on the primary location of Pleasanton, CA is $93,800 - $202,500. Actual pay will be determined based on experience, qualifications, geographic location, and other job-related factors permitted by law. A discretionary annual bonus may be available based on individual and Company performance.This position also qualifies for the benefits detailed at the link provided below.[]Who we areAt Roche, more than 100,000 people across 100 countries are pushing back the frontiers of healthcare. Working together, we've become one of the world's leading research-focused healthcare groups. Our success is built on innovation, curiosity and diversity.Roche is an equal opportunity employer and strictly prohibits unlawful discrimination based upon an individual's race, color, religion, gender, sexual orientation, gender identity/expression, national origin/ancestry, age, mental/physical disability, medical condition, marital status, veteran status, or any other characteristic protected by law.If you have a disability and need an accommodation in relation to the online application process, please contact us by completing this form .
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Keywords: F. Hoffmann-La Roche Gruppe, Manteca , Principal Scientist I, Analytics & Separation Specialist, Oligonucleotide Research, Other , Pleasanton, California